Agmatine Sulfate
Also known as: agmatine, decarboxylated arginine, AgS, AgmaSet
Effective Dosage
2.67 g daily based on clinical studies
What the Science Says
Agmatine sulfate is a compound made from the amino acid arginine. The most credible human evidence comes from small clinical trials showing it may reduce pain and improve quality of life in people with nerve-related conditions like lumbar disc radiculopathy and small fiber neuropathy. Studies used around 2.67 grams per day, and effects were observed within 2–3 weeks of daily use.
What It Doesn't Do
Not proven to build muscle or boost athletic performance — the only muscle-related research involves experimental lab delivery systems, not oral supplements. No evidence it boosts nitric oxide or improves gym pumps in humans. Not a proven treatment for depression, addiction, or general pain. The bodybuilding marketing around this ingredient is way ahead of the actual science.
Evidence-Based Benefits
Agmatine sulfate is a compound made from the amino acid arginine. The most credible human evidence comes from small clinical trials showing it may reduce pain and improve quality of life in people with nerve-related conditions like lumbar disc radiculopathy and small fiber neuropathy. Studies used around 2.67 grams per day, and effects were observed within 2–3 weeks of daily use.
Weak EvidenceEffective at: 2.67 g daily based on clinical studies
Source: auto-research
Absorption & Bioavailability
Unknown from provided studies — oral dosing was used in human trials with apparent clinical effects, but no pharmacokinetic absorption data was reported in the provided papers.
Red Flags to Watch For
- Most human evidence comes from very small, open-label studies — not large, independent RCTs
- The only double-blind placebo-controlled trial had a high dropout rate (51 enrolled, only 31 analyzed in agmatine group)
- Long-term safety data in humans is limited to a single self-reported case study by the researchers themselves
- Widely marketed for gym performance and muscle pumps with zero clinical evidence for those uses
- High doses (3.56 g/day) caused diarrhea and nausea in some participants
- Over 1,000 supplement products contain it despite only 2 relevant clinical trials in the literature
Products Containing Agmatine Sulfate
See how Agmatine Sulfate is used in these analyzed products:
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-10