Amyloglucosidase
Also known as: glucoamylase, glucan 1,4-alpha-glucosidase, AMG, 4-alpha-D-glucan glucohydrolase, EC 3.2.1.3
Effective Dosage
No established dose from provided studies
What the Science Says
Amyloglucosidase is a digestive enzyme that breaks down starch into glucose. In supplement and oral care contexts, it is most studied in combination with glucose oxidase in toothpastes and mouth rinses, where the enzyme pair generates hydrogen peroxide to support the mouth's natural antimicrobial defense system. Some small clinical trials suggest this combination may reduce recurrent mouth ulcers and modestly improve plaque control, though results are inconsistent and effects are generally no better than standard fluoride toothpaste.
What It Doesn't Do
Not proven to be better than regular fluoride toothpaste for plaque or gum health. No solid evidence it prevents cavities on its own. No clinical data supporting use as an oral supplement for digestion, weight loss, or blood sugar control in humans. Don't expect it to cure mouth ulcers — results in studies were mixed. No evidence it improves gut health when swallowed as a capsule.
Evidence-Based Benefits
Amyloglucosidase is a digestive enzyme that breaks down starch into glucose. In supplement and oral care contexts, it is most studied in combination with glucose oxidase in toothpastes and mouth rinses, where the enzyme pair generates hydrogen peroxide to support the mouth's natural antimicrobial defense system. Some small clinical trials suggest this combination may reduce recurrent mouth ulcers and modestly improve plaque control, though results are inconsistent and effects are generally no better than standard fluoride toothpaste.
Weak EvidenceEffective at: No established dose from provided studies
Source: auto-research
Absorption & Bioavailability
Unknown — the provided studies only examine topical oral use (toothpastes, mouth rinses). No data on absorption or systemic bioavailability from oral supplementation.
Red Flags to Watch For
- Most clinical research is on topical oral use (toothpaste/rinse), not swallowed supplements — don't assume oral supplement benefits match
- Always used in combination with glucose oxidase in studies; standalone amyloglucosidase supplement claims are not supported by the provided evidence
- EFSA safety evaluations note it is often produced by genetically modified organisms — check product sourcing if this matters to you
- Small, short-duration trials dominate the evidence base; no large RCTs or meta-analyses found in provided data
- One mouse study suggests that supplemental amyloglucosidase may shift metabolism toward carbohydrate burning and reduce metabolic flexibility — a potential concern for metabolic health
Products Containing Amyloglucosidase
See how Amyloglucosidase is used in these analyzed products:
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-08