Last verified: 17 days ago
BioPerine
Also known as: piperine, black pepper extract, Piper nigrum extract
Evidence under review. — Not yet rated
Black pepper extract used to boost absorption of other supplements. Not proven to work alone.
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What it does
BioPerine is a patented extract of black pepper standardized to piperine, the compound that gives pepper its bite. It is used almost exclusively as a bioavailability enhancer — meaning it is added...
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Evidence quality
Evidence base hasn't been formally rated yet. See research below.
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Clinical dose
2.5–10 mg daily (as bioavailability enhancer)
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Found in
Porefavor, HUM Best of Berberine 1200mg with BioPerine, Lifeseasons Inflamma-X Inflammation Support and 4 more
What the Science Says
BioPerine is a patented extract of black pepper standardized to piperine, the compound that gives pepper its bite. It is used almost exclusively as a bioavailability enhancer — meaning it is added to other supplements to help your body absorb them more effectively. In the provided studies, it was paired with curcuminoids and Nigella sativa oil, where the combined formulas showed benefits for cholesterol and allergy symptoms. BioPerine itself was never tested in isolation in these studies.
What It Doesn't Do
BioPerine alone won't improve your cholesterol, fight allergies, or boost athletic performance — those effects came from the other ingredients it was paired with. No evidence it works as a standalone supplement. Won't help you build muscle or burn fat on its own. The sports performance studies using blends containing BioPerine showed zero benefit over placebo.
Evidence-Based Benefits
Used alongside curcuminoids and other compounds to improve their absorption in the body.
Weak EvidenceEffective at: 2.5–10 mg daily
Supporting studies (click to view on PubMed):
When combined with curcuminoids, helped reduce LDL and triglycerides in metabolic syndrome patients.
Weak EvidenceEffective at: 10 mg piperine with 1000 mg curcuminoids daily
Supporting studies (click to view on PubMed):
Absorption & Bioavailability
Unknown for BioPerine itself — it is the enhancer, not the ingredient being absorbed. Its role is to improve absorption of co-administered compounds, but the provided studies do not isolate or quantify this effect independently.
Red Flags to Watch For
- BioPerine is almost always a minor add-on ingredient; products may use it to justify premium pricing without evidence it meaningfully changes outcomes
- Can interact with medications by affecting drug metabolism enzymes — consult a doctor if you take prescription drugs
- Studies in this dataset tested BioPerine only in combination with other active ingredients, never alone — any claimed standalone benefits are unsupported
- Doses in sports supplements (5–10 mg) showed no performance benefit in two separate RCTs
Products Containing BioPerine
See how BioPerine is used in these analyzed products:
Porefavor
HUM Best of Berberine 1200mg with BioPerine
Supplement
Lifeseasons Inflamma-X Inflammation Support
Supplement
Innerbody Labs Testosterone Support
Supplement
Performance Lab Energy
Supplement
Supergreen Tonik
Supplement
NutraBio Liver
Supplement
Frequently Asked Questions
What does BioPerine do?
Black pepper extract used to boost absorption of other supplements. Not proven to work alone.
What is the effective dose of BioPerine?
2.5–10 mg daily (as bioavailability enhancer)
Is BioPerine safe?
BioPerine is almost always a minor add-on ingredient; products may use it to justify premium pricing without evidence it meaningfully changes outcomes
What doesn't BioPerine do?
BioPerine alone won't improve your cholesterol, fight allergies, or boost athletic performance — those effects came from the other ingredients it was paired with.
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25