Does Bitter Orange Extract Help With P-synephrine, the primary active compound in bitter orang...?

Evidence Summary

P-synephrine, the primary active compound in bitter orange extract, modestly increases resting metabolic rate (RMR); 50 mg alone increased RMR by ~65 kcal compared to placebo, and combinations with naringin and hesperidin increased RMR by up to 183 kcal (PMID: 21537493). At doses up to 98 mg daily for 60 days, bitter orange extract appears safe with no significant changes in blood pressure, heart rate, or blood chemistry (PMID: 23354394, 26948284). It does not appear to cause QTc interval prolongation or significant hemodynamic changes at studied doses (PMID: 16305290, 26948284).

Source: auto-research

Effective Dose

49-104 mg p-synephrine daily based on safety studies; thermogenic effects observed at 50 mg alone or combined with flavonoids