Does Broccoli Extract Help With Broccoli extract, primarily through its active compound s...?

Evidence Summary

Broccoli extract, primarily through its active compound sulforaphane (an isothiocyanate), has shown antioxidant, anti-inflammatory, and modest blood pressure-lowering effects in limited human and animal studies. In a small clinical trial of women with pregnancy hypertension, activated broccoli extract was associated with modest reductions in diastolic blood pressure and circulating sFlt-1 levels (PMID: 33409874). In rodent models, broccoli extract mitigated oxidative stress and tissue damage from toxins such as paraquat and cadmium, and showed chemoprotective effects against carcinogen-induced DNA damage (PMID: 38800031, 37821783, 37821474). In vitro, a myrosinase-activated broccoli extract suppressed angiogenesis by inhibiting the VEGF-VEGFR2 axis in endothelial cells (PMID: 41900141).

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Effective Dose

No established dose from provided studies; animal studies used 100–300 mg/kg; human clinical data limited