Last verified: today
Cascara Sagrada Bark
Also known as: Rhamnus purshiana, Sacred Bark, Chittem Bark, Casanthranol, Cascara Fluidextract
Evidence under review. — Not yet rated
Herbal laxative banned by FDA as OTC drug. No proven detox, weight loss, or GI benefits.
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What it does
Cascara sagrada is the dried bark of the Rhamnus purshiana tree, historically used as a stimulant laxative. Its active compounds, called cascarosides, are anthraquinone glycosides that stimulate...
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Evidence quality
Evidence base hasn't been formally rated yet. See research below.
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Clinical dose
No established dose (insufficient research data)
What the Science Says
Cascara sagrada is the dried bark of the Rhamnus purshiana tree, historically used as a stimulant laxative. Its active compounds, called cascarosides, are anthraquinone glycosides that stimulate the colon. However, the FDA ruled in 2002 that cascara sagrada is not generally recognized as safe and effective as an over-the-counter drug ingredient.
What It Doesn't Do
Does not detoxify your body — no such mechanism exists. Does not improve body composition or reduce waist size. Does not relieve gastrointestinal symptoms better than placebo. Not a safe or effective OTC laxative according to the FDA.
Absorption & Bioavailability
Unknown — cascarosides are the active compounds, but absorption and metabolism data were not covered in the provided studies
Red Flags to Watch For
- FDA ruled cascara sagrada NOT generally recognized as safe and effective as an OTC drug ingredient in 2002
- Often hidden inside proprietary blends, making it impossible to know the actual dose you are getting
- Frequently marketed as a 'detox' ingredient despite no clinical evidence supporting detoxification claims
- A clinical trial found a multi-ingredient supplement containing cascara sagrada produced no improvements in body composition, waist circumference, or GI symptoms vs. placebo
- Long-term stimulant laxative use can cause dependency and electrolyte imbalances
Frequently Asked Questions
What does Cascara Sagrada Bark do?
Herbal laxative banned by FDA as OTC drug. No proven detox, weight loss, or GI benefits.
What is the effective dose of Cascara Sagrada Bark?
No established dose (insufficient research data)
Is Cascara Sagrada Bark safe?
FDA ruled cascara sagrada NOT generally recognized as safe and effective as an OTC drug ingredient in 2002
What doesn't Cascara Sagrada Bark do?
Does not detoxify your body — no such mechanism exists.
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-07-05