Does Citrulline Malate Help With A meta-analysis (PMID: 33308806) found citrulline supplem...?

Evidence Summary

A meta-analysis (PMID: 33308806) found citrulline supplementation significantly reduced post-exercise perceived exertion (RPE) and muscle soreness at 24-48 hours post-exercise across 13 RCTs. One study in hypertensive patients (PMID: 39385595) found a single 6 g dose reduced diastolic blood pressure during waking hours and over 24-hour monitoring. Animal research (PMID: 36251983) suggests CM may improve muscle bioenergetics during repeated fatiguing exercise bouts, though this did not translate to improved mechanical performance.

Source: auto-research

Effective Dose

6-8 g taken 45-120 min before exercise based on study doses