Does Cranberry Juice Concentrate Help With Cranberry's high-molecular-weight fraction (NDM) shows in...?

Evidence Summary

Cranberry's high-molecular-weight fraction (NDM) shows in vitro and small clinical evidence of inhibiting oral bacteria (Streptococcus mutans) and periodontal pathogens, with significant reductions in plaque and salivary S. mutans counts in children using NDM mouthwash (PMID: 25872631). Lab and animal studies suggest cranberry polyphenols may inhibit H. pylori growth (PMID: 19120894) and reduce urinary bladder cancer incidence in rats (PMID: 18497966). The NDM fraction also inhibits MMP and elastase activity relevant to periodontal tissue destruction in vitro (PMID: 17305875, 16473919).

Source: auto-research

Effective Dose

No established dose from provided studies; EFSA evaluated 80 mg PACs/serving for cranberry extract powder (PMID: 32625483)