DHEA
Also known as: Dehydroepiandrosterone, DHEA-S, DHEA-Sulfate, Prasterone
Effective Dosage
No established dose from provided studies
What the Science Says
DHEA (dehydroepiandrosterone) is a hormone naturally produced by the adrenal glands that serves as a precursor to sex hormones like testosterone and estrogen. It rises during adrenarche (around ages 6–8) and peaks in early adulthood, then gradually declines with age. The provided research shows DHEA-S rises in response to acute stress, fluctuates across the menstrual cycle, and is elevated in conditions like PCOS; vaginal DHEA (prasterone) is cited as an FDA-approved option for moderate-to-severe genitourinary syndrome of menopause (GSM).
What It Doesn't Do
The provided studies do not support DHEA supplements for building muscle or boosting athletic performance. No evidence from these papers that oral DHEA supplements reliably improve memory or cognitive function. No data here showing DHEA supplements reverse aging or extend lifespan. Don't expect it to fix hormonal imbalances on its own — the studies show diet and lifestyle changes also significantly alter DHEA-S levels.
Evidence-Based Benefits
DHEA is a hormone produced by the adrenal glands that serves as a precursor to male and female sex hormones. Research indicates that DHEA supplementation may improve bone density, enhance mood, and support adrenal function, particularly in older adults.
Strong EvidenceEffective at: 25-50 mg daily
Source: auto-research
Absorption & Bioavailability
Unknown from provided studies — oral bioavailability and conversion rates to active hormones are not addressed in the provided papers. Vaginal DHEA (prasterone) is noted as an FDA-approved local delivery route for GSM.
Red Flags to Watch For
- DHEA is a hormone precursor — supplementing it can raise testosterone and estrogen levels unpredictably, which may be harmful in hormone-sensitive conditions like breast or prostate cancer
- The provided studies used DHEA injections in animal PCOS models (60 mg/kg), not human oral supplements — animal doses cannot be directly applied to humans
- DHEA-S levels naturally fluctuate with stress, menstrual cycle phase, and physical activity — a single blood test may not reflect true baseline levels
- Over 1,000 supplement products contain DHEA (NIH DSLD), but the provided clinical evidence for oral supplementation in healthy adults is extremely limited
- Oral DHEA supplements are not FDA-approved for most marketed uses; only vaginal DHEA (prasterone) has FDA approval for a specific indication (GSM)
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-06