Last verified: 17 days ago
DHM (Dihydromyricetin)
Also known as: Dihydromyricetin, Ampelopsin, DHM, Hovenia dulcis extract
Evidence under review. — Not yet rated
Plant flavonoid studied for alcohol metabolism support and hangover relief. Evidence is still early-stage.
-
What it does
DHM (Dihydromyricetin) is a natural flavonoid extracted from the Japanese raisin tree (Hovenia dulcis), used in traditional East Asian medicine for centuries to counter alcohol intoxication. It is...
-
Evidence quality
Evidence base hasn't been formally rated yet. See research below.
-
Clinical dose
300-600 mg daily based on general knowledge (no confirmed dose from provided studies)
-
Found in
Molly J Revive Hangover Helper, No Days Wasted DHM Detox, Flyby Recovery Capsules and 1 more
What the Science Says
DHM (Dihydromyricetin) is a natural flavonoid extracted from the Japanese raisin tree (Hovenia dulcis), used in traditional East Asian medicine for centuries to counter alcohol intoxication. It is thought to support the liver's ability to break down alcohol and its toxic byproduct acetaldehyde, potentially reducing hangover symptoms. Some preliminary research also suggests it may interact with GABA receptors in the brain, which could help reduce alcohol-related sedation and anxiety — but this is based on early animal and limited human data, not large clinical trials.
What It Doesn't Do
Not a proven hangover cure — no large clinical trials confirm it eliminates hangovers. Won't make it safe to drink more alcohol. Not a treatment for alcohol use disorder or liver disease. No solid evidence it boosts athletic performance or burns fat. Marketing claims about 'sobriety in a pill' are not backed by science.
Evidence-Based Benefits
May reduce hangover symptoms like nausea and headache when taken before or after drinking.
Weak EvidenceEffective at: 300-600 mg (general knowledge; no confirmed clinical dose)
May help the liver break down alcohol and acetaldehyde more efficiently.
Weak EvidenceEffective at: No established dose
Shows preliminary liver-protective effects in animal models of alcohol-induced damage.
Weak EvidenceEffective at: No established dose
Absorption & Bioavailability
Unknown — limited human pharmacokinetic data available. Animal studies suggest moderate absorption, but human bioavailability has not been well characterized in the provided or widely published literature.
Red Flags to Watch For
- No large-scale human clinical trials confirm safety or efficacy — most evidence comes from animal studies or small pilot trials
- Products marketed as 'hangover cures' or 'sobriety pills' are making claims far beyond what the science supports
- May interact with alcohol metabolism enzymes — potential for unexpected drug or alcohol interactions not fully studied
- Supplement doses vary widely across products (100 mg to 1000 mg+) with no established optimal human dose
- Some products combine DHM with other unproven ingredients, making it impossible to attribute any effect to DHM alone
Products Containing DHM (Dihydromyricetin)
See how DHM (Dihydromyricetin) is used in these analyzed products:
Frequently Asked Questions
What does DHM (Dihydromyricetin) do?
Plant flavonoid studied for alcohol metabolism support and hangover relief. Evidence is still early-stage.
What is the effective dose of DHM (Dihydromyricetin)?
300-600 mg daily based on general knowledge (no confirmed dose from provided studies)
Is DHM (Dihydromyricetin) safe?
No large-scale human clinical trials confirm safety or efficacy — most evidence comes from animal studies or small pilot trials
What doesn't DHM (Dihydromyricetin) do?
Not a proven hangover cure — no large clinical trials confirm it eliminates hangovers.
Research Sources
- General knowledge — no paper abstracts were provided for this analysis. Limited published research available.
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25