DHM (Dihydromyricetin)
Also known as: Dihydromyricetin, Ampelopsin, DHM, Hovenia dulcis extract
Effective Dosage
300-600 mg per occasion; No well-established daily dose
What the Science Says
DHM (Dihydromyricetin) is a natural flavonoid compound extracted primarily from the Japanese raisin tree (Hovenia dulcis), a plant used in traditional Asian medicine for centuries to ease alcohol-related discomfort. It is most commonly marketed as a hangover remedy, with early research suggesting it may help the body process alcohol faster and reduce some effects of intoxication by interacting with GABA receptors in the brain. Some preliminary studies also suggest potential liver-protective properties, though the human clinical evidence base is still very small and most findings come from animal or cell studies.
What It Doesn't Do
Won't cure a hangover guaranteed — human evidence is thin. Not a proven liver treatment or substitute for medical care. Won't let you drink more safely or eliminate alcohol's harmful effects. Not a detox solution despite how it's often marketed. No solid evidence it improves cognitive function or athletic performance.
Evidence-Based Benefits
May enhance alcohol metabolism enzymes (ADH/ALDH) in rats. Limited human evidence.
Weak EvidenceEffective at: 300-600mg (extrapolated from rat studies)
Source: Examine.com, PubMed
Absorption & Bioavailability
Poor to Moderate — DHM has low natural bioavailability due to limited water solubility and rapid metabolism. Some formulations use enhanced delivery methods, but absorption data in humans is very limited.
Red Flags to Watch For
- Most supporting evidence comes from animal studies, not human clinical trials — marketing often overstates the human data
- No standardized dose has been established through rigorous clinical research
- Products vary widely in purity and DHM concentration — no regulatory standard exists
- Marketing as a 'hangover cure' may encourage riskier drinking behavior
- Potential interactions with medications metabolized by the liver have not been well studied in humans
Research Sources
- General knowledge — no paper abstracts were provided for this analysis. Limited published clinical research available.
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-06