Last verified: today
Digezyme
Also known as: DigeZyme®, Multienzyme Complex, MEC, digestive enzyme blend
Evidence under review. — Not yet rated
Proprietary digestive enzyme blend with one RCT showing relief from indigestion symptoms.
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What it does
Digezyme is a proprietary blend of digestive enzymes — including amylase, protease, lipase, cellulase, and lactase — manufactured by Sabinsa Corporation. The one available clinical trial found...
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Evidence quality
Evidence base hasn't been formally rated yet. See research below.
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Clinical dose
No established dose from provided studies
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Found in
What the Science Says
Digezyme is a proprietary blend of digestive enzymes — including amylase, protease, lipase, cellulase, and lactase — manufactured by Sabinsa Corporation. The one available clinical trial found that taking Digezyme for 60 days significantly reduced symptoms of functional dyspepsia (chronic indigestion) compared to placebo, with no reported adverse events. The manufacturer also claims it may help with post-exercise muscle soreness, but that claim is not supported by any peer-reviewed study in the provided data.
What It Doesn't Do
Not proven to improve digestion in healthy people without digestive complaints. The muscle soreness claim comes from the manufacturer's website, not independent peer-reviewed research. Don't assume it works the same as prescription digestive enzymes for conditions like pancreatic insufficiency. One small industry-linked study is not enough to call this a proven treatment for any condition.
Evidence-Based Benefits
Reduces symptoms of functional dyspepsia (chronic indigestion) after 60 days of use.
Weak EvidenceEffective at: No established dose from provided studies
Supporting studies (click to view on PubMed):
Well-tolerated with no reported adverse events in a 60-day clinical trial.
Weak EvidenceEffective at: No established dose from provided studies
Supporting studies (click to view on PubMed):
Absorption & Bioavailability
Unknown — enzyme activity in the gut is plausible given the mechanism, but absorption and systemic bioavailability of the enzyme blend itself is not addressed in the provided studies.
Red Flags to Watch For
- Only one published RCT exists for this specific proprietary blend, limiting confidence in the evidence
- The sole clinical study was authored by M. Majeed, who is affiliated with Sabinsa, the manufacturer of DigeZyme — a significant conflict of interest
- Muscle soreness claims promoted on the manufacturer's website are not backed by peer-reviewed studies in the provided data
- Dose information is not clearly disclosed in the available abstract, making it hard to evaluate whether commercial products use clinically relevant amounts
- 148 registered supplement products contain this ingredient, suggesting widespread use well ahead of the evidence base
Products Containing Digezyme
See how Digezyme is used in these analyzed products:
Frequently Asked Questions
What does Digezyme do?
Proprietary digestive enzyme blend with one RCT showing relief from indigestion symptoms.
What is the effective dose of Digezyme?
No established dose from provided studies
Is Digezyme safe?
Only one published RCT exists for this specific proprietary blend, limiting confidence in the evidence
What doesn't Digezyme do?
Not proven to improve digestion in healthy people without digestive complaints.
Research Sources
- PubMed
- NIH DSLD
- Web
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-11-09