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DIM (Diindolylmethane)

Also known as: Diindolylmethane, 3,3'-Diindolylmethane, DIM, I3C metabolite

Evidence under review. — Not yet rated

Plant compound from cruciferous veggies; may support estrogen balance, but clinical evidence is limited.

  • What it does

    DIM is a natural compound formed when you digest cruciferous vegetables like broccoli, cabbage, and Brussels sprouts. It is most studied for its effects on estrogen metabolism — specifically, it...

  • Evidence quality

    Evidence base hasn't been formally rated yet. See research below.

  • Clinical dose

    100-300 mg daily (no established dose from provided studies)

See full breakdown ↓ Methodology →

What the Science Says

DIM is a natural compound formed when you digest cruciferous vegetables like broccoli, cabbage, and Brussels sprouts. It is most studied for its effects on estrogen metabolism — specifically, it may shift the body toward producing less potent forms of estrogen, which some researchers believe could support hormonal balance in both men and women. Preliminary research also suggests possible roles in immune modulation and cellular health, though robust clinical evidence is lacking and no firm dosing guidelines exist from the studies provided.

What It Doesn't Do

Won't balance your hormones overnight. No proven cancer treatment or prevention — don't believe marketing that says otherwise. Eating more broccoli is NOT the same as taking a concentrated DIM supplement. No solid evidence it boosts testosterone in healthy men. Not a weight-loss solution despite some marketing claims.

Evidence-Based Benefits

May shift estrogen breakdown toward less potent metabolites in some adults.

Weak Evidence

Effective at: 100-300 mg daily

Preliminary evidence suggests it may support hormone balance in women with estrogen dominance symptoms.

Weak Evidence

Effective at: 150-300 mg daily

Absorption & Bioavailability

Poor to Moderate — DIM has low natural bioavailability and is often formulated with absorption enhancers (e.g., BioPerine, phospholipid complexes). Standard DIM supplements without these enhancers may absorb poorly. No bioavailability data from provided studies.

Red Flags to Watch For

  • Products making anti-cancer claims are not FDA-approved and may be misleading or dangerous
  • High doses may disrupt hormone balance rather than support it — more is not better
  • May interact with hormonal medications, birth control, or hormone therapies
  • Pregnant or breastfeeding women should avoid DIM supplements due to unknown safety profile
  • 568 registered supplement products suggests heavy commercialization with marketing often outpacing the science

Research Sources

  • General knowledge — no paper abstracts were provided for this analysis. Limited published clinical research available.

This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25