Last verified: 17 days ago
Eleuthero
Also known as: Siberian Ginseng, Eleutherococcus senticosus, Siberian Eleuthero, Eleuthero root
Evidence under review. — Not yet rated
Adaptogenic herb with very limited clinical evidence; may interact with drug-metabolizing enzymes.
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What it does
Eleuthero is a root herb traditionally used as an adaptogen — a plant thought to help the body handle stress. It appears in many multi-ingredient supplement blends marketed for energy, fat loss,...
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Evidence quality
Evidence base hasn't been formally rated yet. See research below.
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Clinical dose
No established dose (insufficient research data)
What the Science Says
Eleuthero is a root herb traditionally used as an adaptogen — a plant thought to help the body handle stress. It appears in many multi-ingredient supplement blends marketed for energy, fat loss, and endurance. The only relevant finding from the provided research is that Siberian Eleuthero inhibited the CYP3A4 enzyme in lab cells, which is important for how the body processes many medications. No clinical trials on Eleuthero alone were found in the provided data.
What It Doesn't Do
No proof it reduces stress or fatigue on its own. No evidence from these studies it boosts athletic performance. No data showing it burns fat. Don't assume it's safe just because it's 'natural' — it may interfere with prescription drugs.
Evidence-Based Benefits
Siberian Eleuthero inhibits CYP3A4, an enzyme that processes many common medications.
Weak EvidenceEffective at: No established dose
Supporting studies (click to view on PubMed):
Absorption & Bioavailability
Unknown — no pharmacokinetic data available from the provided studies
Red Flags to Watch For
- Siberian Eleuthero inhibited CYP3A4 more potently than a standard drug inhibitor in lab tests — this means it could raise blood levels of many prescription medications to dangerous levels
- Almost always sold in multi-ingredient blends, making it impossible to isolate its individual effects or dose
- No standalone clinical trials were found in the provided data to support any specific health claim
- Widely used in over 1,000 registered supplement products despite very limited clinical evidence
Products Containing Eleuthero
See how Eleuthero is used in these analyzed products:
Frequently Asked Questions
What does Eleuthero do?
Adaptogenic herb with very limited clinical evidence; may interact with drug-metabolizing enzymes.
What is the effective dose of Eleuthero?
No established dose (insufficient research data)
Is Eleuthero safe?
Siberian Eleuthero inhibited CYP3A4 more potently than a standard drug inhibitor in lab tests — this means it could raise blood levels of many prescription medications to dangerous levels
What doesn't Eleuthero do?
No proof it reduces stress or fatigue on its own.
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25