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Epigallocatechin-3-Gallate (EGCG)

Also known as: EGCG, epigallocatechin gallate, green tea catechin, green tea extract

Evidence under review. — Not yet rated

Green tea's main antioxidant. Early research shows anti-inflammatory and neuroprotective potential, but human evidence is limited.

  • What it does

    EGCG is the most abundant and biologically active polyphenol found in green tea. In lab and animal studies, it shows antioxidant, anti-inflammatory, and anti-cancer properties by targeting...

  • Evidence quality

    Evidence base hasn't been formally rated yet. See research below.

  • Clinical dose

    No established dose from provided studies

See full breakdown ↓ Methodology →

What the Science Says

EGCG is the most abundant and biologically active polyphenol found in green tea. In lab and animal studies, it shows antioxidant, anti-inflammatory, and anti-cancer properties by targeting multiple cellular pathways. Early human trials suggest it may support cognitive function when combined with lifestyle interventions, and one small trial found inhaled EGCG was well-tolerated in cancer patients with COVID-19 pneumonia — but large, confirmatory human trials are still lacking.

What It Doesn't Do

Not proven to prevent Alzheimer's or Parkinson's disease in humans. No solid evidence it burns fat or boosts metabolism on its own. Won't replace cancer treatment. The cognitive benefits seen in one trial were not statistically significant on the primary outcome. Don't expect dramatic results from a supplement alone.

Evidence-Based Benefits

May enhance cognitive benefits of lifestyle interventions in older adults at risk for cognitive decline.

Weak Evidence

Effective at: 5-6 mg/kg/day

Short-term use at 720 mg/day does not reduce folate levels in reproductive-age women.

Weak Evidence

Effective at: 720 mg/day

Inhaled EGCG was well-tolerated and showed early signs of benefit in cancer patients with COVID-19 pneumonia.

Weak Evidence

Effective at: 10 mL nebulized 3x/day for 7+ days

Absorption & Bioavailability

Poor — EGCG is rapidly metabolized and has low oral bioavailability. Protein carriers (like albumin) and nanoparticle formulations are being studied to improve stability and absorption, but these are not yet standard in consumer products.

Red Flags to Watch For

  • High doses may interact with folate metabolism — relevant for women of childbearing age, though one 30-day trial at 720 mg/day found no folate deficiency
  • Potential interactions with medications not well characterized in the provided studies
  • Most compelling anti-cancer and neuroprotective evidence comes from lab and animal studies, not human trials
  • Nebulized/inhaled EGCG formulations used in one trial are not the same as standard oral supplements sold to consumers
  • Products vary widely in EGCG concentration and purity — 1,000+ registered supplement products with no standardized dosing

Research Sources

  • PubMed
  • NIH DSLD

This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25