Last verified: 17 days ago
Fisetin
Also known as: 3,3',4',7-tetrahydroxyflavone, fisetin flavonoid, dietary flavonoid
Evidence under review. — Not yet rated
Plant flavonoid with senolytic and antioxidant properties. Most evidence is preclinical; human data is very limited.
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What it does
Fisetin is a natural flavonoid found in fruits and vegetables like strawberries, apples, and onions. It is being studied primarily as a 'senolytic' — a compound that may help clear damaged, aging...
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Evidence quality
Evidence base hasn't been formally rated yet. See research below.
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Clinical dose
No established dose from provided studies
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Found in
What the Science Says
Fisetin is a natural flavonoid found in fruits and vegetables like strawberries, apples, and onions. It is being studied primarily as a 'senolytic' — a compound that may help clear damaged, aging cells from the body, which researchers believe contributes to inflammation and age-related disease. Early animal studies and limited human data suggest it may reduce markers of cellular senescence and oxidative stress, but robust human clinical trials are largely absent from the current evidence base.
What It Doesn't Do
Not proven to extend human lifespan. No solid human evidence it improves memory or cognition on its own. Not a proven cancer treatment — lab and animal findings don't translate directly to humans. No confirmed benefit for liver function or blood lipids in humans. Don't expect anti-aging results from typical supplement doses — human pharmacokinetic data shows very poor absorption without special formulations.
Evidence-Based Benefits
A novel hydrogel formulation increases fisetin absorption by nearly 27-fold compared to standard unformulated fisetin.
Weak EvidenceEffective at: 1000 mg FF-20 formulation (delivering 192 mg fisetin)
Supporting studies (click to view on PubMed):
Fisetin reduced markers of cellular senescence and improved vascular function in mice exposed to the chemotherapy drug doxorubicin.
Weak EvidenceEffective at: 100 mg/kg/day intermittent (animal study only)
Supporting studies (click to view on PubMed):
Fisetin selectively clears senescent cells by inhibiting anti-apoptotic pathways, based on preclinical and review evidence.
Weak EvidenceEffective at: No established human dose
Supporting studies (click to view on PubMed):
Absorption & Bioavailability
Poor — standard oral fisetin is poorly absorbed. One human pharmacokinetic study found a novel hydrogel encapsulation (FF-20) increased plasma levels 26.9-fold compared to unformulated fisetin, suggesting standard supplements may deliver very little active compound.
Red Flags to Watch For
- Extremely poor bioavailability with standard formulations — most supplements on the market may not deliver meaningful blood levels
- Nearly all compelling evidence (senolysis, cancer, vascular protection) comes from animal or cell studies, not human trials
- The one human RCT testing fisetin as part of a combination extract found no significant effect on liver function or lipid profiles
- High-dose use (100 mg/kg in animals) has not been validated for safety or efficacy in humans at equivalent doses
- 87 registered supplement products exist despite minimal human clinical evidence — marketing far outpaces the science
Products Containing Fisetin
See how Fisetin is used in these analyzed products:
Frequently Asked Questions
What does Fisetin do?
Plant flavonoid with senolytic and antioxidant properties. Most evidence is preclinical; human data is very limited.
What is the effective dose of Fisetin?
No established dose from provided studies
Is Fisetin safe?
Extremely poor bioavailability with standard formulations — most supplements on the market may not deliver meaningful blood levels
What doesn't Fisetin do?
Not proven to extend human lifespan.
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25