Does Garcinia Cambogia Help With Garcinia cambogia's active compound, hydroxycitric acid (...?
Weak EvidenceEvidence Summary
Garcinia cambogia's active compound, hydroxycitric acid (HCA), has shown modest effects on glycemia reduction in healthy individuals via intraduodenal administration, though no effect was observed in type 2 diabetes patients (PMID: 26792024). In a small RCT, Garcinia extract (500 mg TID) reduced prostate volume and PSA levels in LUTS/BPH patients, with enhanced outcomes when combined with Silodosin (PMID: 40209997). Animal and in vitro studies suggest HCA may inhibit fatty acid synthesis and reduce hepatic lipid accumulation, but these findings have not been robustly replicated in human clinical trials (PMID: 28877777, PMID: 37050928).
Source: auto-research
Effective Dose
No established dose from provided studies for weight loss; 500 mg TID (1500 mg/day) used in LUTS/BPH trial (PMID: 40209997); 2800 mg intraduodenal HCA used in glycemia trial (PMID: 26792024)