Does Glutamine Help With One small RCT (PMID: 41924221) found that calcium + gluta...?

Evidence Summary

One small RCT (PMID: 41924221) found that calcium + glutamine co-supplementation (10g/day glutamine, 500mg/day calcium) significantly improved bone mineral density in young female athletes with menstrual disorders over 90 days, though the effect was strongest for the combination rather than glutamine alone. Glutamine has been proposed as an oral supplement to replenish presynaptic glutamate stores and buffer against excitotoxic spill-over in the context of Alzheimer's disease prevention and antidepressant regimens (PMID: 41929967, 41924710), but these are hypothesis papers without clinical trial data. Aerobic exercise was associated with significant changes in plasma glutamine levels in Parkinson's disease patients (PMID: 41205731), suggesting glutamine may be a responsive biomarker of metabolic activity rather than a direct therapeutic agent.

Source: auto-research

Effective Dose

10,000 mg/day based on one RCT (PMID: 41924221); No established dose for other claimed uses