Gotu Kola
Also known as: Centella asiatica, Indian Pennywort, Brahmi (sometimes), Mandukparni
Effective Dosage
No established dose from provided studies
What the Science Says
Gotu Kola is a leafy herb used for centuries in Ayurvedic and traditional Chinese medicine. In a small human trial, a single large dose reduced the startle response — a marker of anxiety — suggesting mild calming effects. Animal studies suggest it may protect the liver, stomach lining, and brain neurons from damage, but these findings have not been confirmed in human clinical trials.
What It Doesn't Do
Not proven to boost memory or cognition in healthy adults — a combination supplement containing gotu kola showed no cognitive benefit over placebo. Won't treat Alzheimer's disease in humans based on current evidence. No proof it burns thigh fat on its own — the topical study combined it with multiple other ingredients, diet, and exercise. Not a proven antidepressant in humans. Animal liver and gut protection results don't automatically translate to people.
Evidence-Based Benefits
Gotu Kola is a leafy herb used for centuries in Ayurvedic and traditional Chinese medicine. In a small human trial, a single large dose reduced the startle response — a marker of anxiety — suggesting mild calming effects. Animal studies suggest it may protect the liver, stomach lining, and brain neurons from damage, but these findings have not been confirmed in human clinical trials.
Weak EvidenceEffective at: No established dose from provided studies
Source: auto-research
Absorption & Bioavailability
Unknown — no pharmacokinetic data provided in the available studies. Oral dosing was used in human trials, but absorption rates were not reported.
Red Flags to Watch For
- Allergic contact dermatitis has been reported with topical Centella asiatica extract — patch testing recommended before skin use
- Most compelling evidence (liver protection, neuroprotection, gut protection) comes from animal studies only — human translation is unproven
- The only human cognitive study showed no benefit and one test actually favored placebo
- Topical fat-loss study used a multi-ingredient product with diet and exercise — impossible to isolate gotu kola's contribution
- Widely sold in over 1,000 registered supplement products despite very limited human clinical trial data
Products Containing Gotu Kola
See how Gotu Kola is used in these analyzed products:
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-09