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Graviola Extract

Also known as: Annona muricata, Soursop, Guanabana, Custard Apple

Evidence under review. — Not yet rated

Tropical plant extract with early-stage lab research only. No human clinical trials support its use.

  • What it does

    Graviola is an extract from the leaves or fruit of the tropical soursop tree (Annona muricata). Early laboratory and animal studies have explored its potential antioxidant, liver-protective, and...

  • Evidence quality

    Evidence base hasn't been formally rated yet. See research below.

  • Clinical dose

    No established dose (insufficient research data)

See full breakdown ↓ Methodology →

What the Science Says

Graviola is an extract from the leaves or fruit of the tropical soursop tree (Annona muricata). Early laboratory and animal studies have explored its potential antioxidant, liver-protective, and anti-cancer cell properties. All available research comes from cell cultures or rodent models — no human clinical trials have been conducted to confirm these effects in people.

What It Doesn't Do

Does NOT treat or cure cancer in humans — zero clinical trial evidence. Not a proven liver detox supplement. No evidence it works as an immune booster in people. Marketing claims about 'killing cancer cells' are based on lab dish studies, not human data.

Evidence-Based Benefits

May reduce liver damage markers in rats exposed to toxic compounds.

Weak Evidence

Effective at: 200 mg/kg in animal studies (no human equivalent established)

Shows antioxidant properties in animal models of oxidative stress.

Weak Evidence

Effective at: No established human dose

Extracts show anti-tumor activity in mouse xenograft and cell culture models.

Weak Evidence

Effective at: No established human dose

Absorption & Bioavailability

Unknown — no human pharmacokinetic or absorption studies found in the provided data.

Red Flags to Watch For

  • No human clinical trials exist in the provided evidence base — all research is animal or cell-based
  • Graviola contains annonacin, a neurotoxin linked to atypical Parkinson's-like neurodegeneration with long-term use
  • Widely marketed as a cancer cure or treatment — a claim with zero clinical trial support
  • Sold in over 1,000 registered supplement products despite a near-total absence of human safety and efficacy data
  • Hormetic dose effects observed in cell studies — meaning the same extract may promote or harm cell survival depending on dose

Research Sources

  • PubMed
  • NIH DSLD

This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25