Last verified: 17 days ago
IP-PA1 (Immunopotentiator from Pantoea agglomerans 1)
Also known as: IP-PA1, Pantoea agglomerans extract, LPS from Pantoea agglomerans, wheat bran extract immunopotentiator
Evidence under review. — Not yet rated
Bacterial-derived immune compound with very limited published research. Effects in humans are largely unproven.
-
What it does
IP-PA1 is a lipopolysaccharide-like compound extracted from Pantoea agglomerans, a bacterium found naturally in wheat bran and other plant materials. It is marketed as an immune system activator,...
-
Evidence quality
Evidence base hasn't been formally rated yet. See research below.
-
Clinical dose
No established dose
-
Found in
What the Science Says
IP-PA1 is a lipopolysaccharide-like compound extracted from Pantoea agglomerans, a bacterium found naturally in wheat bran and other plant materials. It is marketed as an immune system activator, theorized to stimulate innate immune responses by interacting with immune cell receptors. Despite appearing in over 1,000 registered supplement products, virtually no peer-reviewed clinical trial data is publicly available to confirm its effectiveness or safe dosing in humans.
What It Doesn't Do
Not proven to prevent colds or flu. No clinical evidence it fights cancer or serious infections. Don't assume 'natural bacterial origin' means safe or effective. Being in 1,000 products doesn't mean it works — that's a marketing footprint, not a science footprint.
Absorption & Bioavailability
Unknown — no published pharmacokinetic or absorption data available from provided studies
Red Flags to Watch For
- No peer-reviewed clinical trials available to verify safety or efficacy in humans
- Derived from a bacterium (Pantoea agglomerans) that can be an opportunistic pathogen — immune-compromised individuals should exercise caution
- Widespread use in supplement products (1,000+ registered) is not matched by published research — high commercial adoption without scientific validation is a red flag
- Lipopolysaccharide-based compounds can trigger inflammatory responses; systemic immune stimulation without medical supervision carries risk
- No established safe dosing range published in the scientific literature
Products Containing IP-PA1 (Immunopotentiator from Pantoea agglomerans 1)
See how IP-PA1 (Immunopotentiator from Pantoea agglomerans 1) is used in these analyzed products:
Frequently Asked Questions
What does IP-PA1 (Immunopotentiator from Pantoea agglomerans 1) do?
Bacterial-derived immune compound with very limited published research. Effects in humans are largely unproven.
What is the effective dose of IP-PA1 (Immunopotentiator from Pantoea agglomerans 1)?
No established dose
Is IP-PA1 (Immunopotentiator from Pantoea agglomerans 1) safe?
No peer-reviewed clinical trials available to verify safety or efficacy in humans
What doesn't IP-PA1 (Immunopotentiator from Pantoea agglomerans 1) do?
Not proven to prevent colds or flu.
Research Sources
- General knowledge — no papers were provided. Limited published research available.
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25