Last verified: 17 days ago
KSM-66 Ashwagandha
Also known as: Withania somnifera, Indian ginseng, winter cherry, ashwagandha root extract
Evidence under review. — Not yet rated
Adaptogenic herb. Commonly used to reduce stress, lower cortisol, and support sleep and recovery.
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What it does
KSM-66 is a branded, full-spectrum ashwagandha root extract standardized to at least 5% withanolides — the active compounds thought to drive its effects. It is one of the most studied forms of...
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Evidence quality
Evidence base hasn't been formally rated yet. See research below.
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Clinical dose
300-600 mg daily (root extract, standardized to ≥5% withanolides)
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Found in
WeightWorld Ashwagandha KSM-66 Tablets, Moon Juice SuperYou, TestoPrime and 6 more
What the Science Says
KSM-66 is a branded, full-spectrum ashwagandha root extract standardized to at least 5% withanolides — the active compounds thought to drive its effects. It is one of the most studied forms of ashwagandha and is widely used to help the body manage stress, support healthy cortisol levels, and improve sleep quality. Benefits are generally reported after 4–8 weeks of consistent daily use at doses of 300–600 mg.
What It Doesn't Do
Won't eliminate anxiety or replace professional mental health treatment. Not a proven testosterone booster despite common marketing claims. Won't build muscle on its own — any fitness benefits require actual training. Not a sleep medication. Results vary widely between individuals.
Evidence-Based Benefits
May help reduce perceived stress and lower cortisol levels in chronically stressed adults.
Moderate EvidenceEffective at: 300-600 mg daily
May improve sleep onset and overall sleep quality in adults with mild insomnia or stress-related poor sleep.
Moderate EvidenceEffective at: 300-600 mg daily
May support muscle strength and recovery when combined with resistance training.
Weak EvidenceEffective at: 300-600 mg daily
May support memory and attention in healthy adults under stress.
Weak EvidenceEffective at: 300-600 mg daily
Absorption & Bioavailability
Moderate — KSM-66 uses a water and milk extraction process designed to preserve the full spectrum of root compounds. Standardization to withanolides improves consistency, but absorption data from the provided studies is unavailable.
Red Flags to Watch For
- Rare but reported cases of liver injury linked to ashwagandha supplements — consult a doctor if you have liver conditions
- May interact with thyroid medications — ashwagandha can influence thyroid hormone levels
- Avoid during pregnancy — traditional use and some research suggest it may stimulate uterine contractions
- Many products use 'ashwagandha' loosely — verify the label specifically says KSM-66 and lists withanolide percentage
- Supplements are not FDA-approved; quality and dosing can vary significantly between brands
Products Containing KSM-66 Ashwagandha
See how KSM-66 Ashwagandha is used in these analyzed products:
WeightWorld Ashwagandha KSM-66 Tablets
Supplement
Moon Juice SuperYou
TestoPrime
Supplement
Eversmithorganics
Supplement
Lemme Chill Ashwagandha Gummies
Supplement
BrainMD Stress Relief Sleep
Supplement
Calm My Brain
Supplement
BPI Sports Best Test 120 Tablets
Supplement
SuperYou
Supplement
Frequently Asked Questions
What does KSM-66 Ashwagandha do?
Adaptogenic herb. Commonly used to reduce stress, lower cortisol, and support sleep and recovery.
What is the effective dose of KSM-66 Ashwagandha?
300-600 mg daily (root extract, standardized to ≥5% withanolides)
Is KSM-66 Ashwagandha safe?
Rare but reported cases of liver injury linked to ashwagandha supplements — consult a doctor if you have liver conditions
What doesn't KSM-66 Ashwagandha do?
Won't eliminate anxiety or replace professional mental health treatment.
Research Sources
- General knowledge — no papers were provided for this analysis. Claims reflect commonly cited research on KSM-66 ashwagandha but are not verified against specific provided studies.
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25