Last verified: 17 days ago
Myo-Inositol
Also known as: inositol, myo-inositol, MI, cyclohexanehexol
Evidence under review. — Not yet rated
Natural compound that supports insulin sensitivity and hormone balance, especially in PCOS and pregnancy.
-
What it does
Myo-inositol is a naturally occurring sugar alcohol that acts as a cellular messenger, particularly in insulin signaling pathways. In women with PCOS, supplementation has been shown to reduce...
-
Evidence quality
Evidence base hasn't been formally rated yet. See research below.
-
Clinical dose
2-4 g daily based on study doses
-
Found in
Wholesome Story Inositol (Myo-Inositol), Asquarednutrition, Ovasitol Plus and 2 more
What the Science Says
Myo-inositol is a naturally occurring sugar alcohol that acts as a cellular messenger, particularly in insulin signaling pathways. In women with PCOS, supplementation has been shown to reduce markers of insulin resistance (HOMA-IR) and lower levels of asprosin, an adipokine linked to metabolic dysfunction. In pregnant women, 2 g daily alongside folic acid has been associated with reduced insulin resistance and lower asprosin levels compared to folic acid alone.
What It Doesn't Do
Not a proven treatment for impulsivity or mood disorders. No solid evidence it works as a standalone mental health supplement. Don't expect it to replace metformin or other diabetes medications. Plant stress research doesn't translate to human benefits.
Evidence-Based Benefits
Reduces insulin resistance markers in women with PCOS, comparable to early metformin effects.
Weak EvidenceEffective at: 40:1 myo-inositol/D-chiro-inositol combination, 12–16 weeks
Supporting studies (click to view on PubMed):
Lowers insulin resistance and asprosin levels in pregnant women when taken with folic acid.
Weak EvidenceEffective at: 2 g daily with 200 mcg folic acid
Supporting studies (click to view on PubMed):
Supports hormonal and metabolic balance in women with PCOS as a nutraceutical adjunct.
Weak EvidenceEffective at: No established dose from provided studies
Supporting studies (click to view on PubMed):
Absorption & Bioavailability
Unknown from provided studies — pharmacokinetics noted in preclinical models (rats, mice) but human absorption data not detailed in the provided papers
Red Flags to Watch For
- Most human clinical trials in the provided data are small pilot studies (30–40 participants), limiting confidence in results
- Effects on asprosin and insulin resistance are promising but not yet confirmed in large-scale RCTs
- Often combined with D-chiro-inositol or folic acid in studies — solo myo-inositol effects are harder to isolate
- Many products on the market contain unverified ratios or doses not tested in clinical trials
Products Containing Myo-Inositol
See how Myo-Inositol is used in these analyzed products:
Frequently Asked Questions
What does Myo-Inositol do?
Natural compound that supports insulin sensitivity and hormone balance, especially in PCOS and pregnancy.
What is the effective dose of Myo-Inositol?
2-4 g daily based on study doses
Is Myo-Inositol safe?
Most human clinical trials in the provided data are small pilot studies (30–40 participants), limiting confidence in results
What doesn't Myo-Inositol do?
Not a proven treatment for impulsivity or mood disorders.
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25