Does Nattokinase Help With Nattokinase has demonstrated modest lipid-lowering effect...?

Evidence Summary

Nattokinase has demonstrated modest lipid-lowering effects (reducing TC, LDL-C, non-HDL-C) when combined with Monascus in a 4-month RCT (PMID: 37836525), and showed safety and symptom improvement in vascular disease patients including DVT and venous insufficiency (PMID: 34199189). In a stroke rehabilitation context, it showed supportive effects on functional recovery scores as an adjunct to standard care (PMID: 31934821), and animal models suggest neuroprotective mechanisms via Nrf2-associated antioxidative pathways (PMID: 41760340).

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Effective Dose

2000-8000 FU/day based on clinical trials; no consensus established