Nitrosigine

Also known as: Inositol-Stabilized Arginine Silicate, ASI, arginine silicate inositol

Evidence under review. — Not yet rated

Patented arginine compound shown to boost blood flow and may support focus in active adults.

What it does

Nitrosigine is a patented form of arginine bonded with silicate and stabilized by inositol, designed to raise nitric oxide levels more effectively than plain arginine. In a small clinical trial, a...
Evidence quality

Evidence base hasn't been formally rated yet. See research below.
Clinical dose

1.5 g daily based on study doses
Found in

BEYOND RAW (Brand), Bucked Up Non-Stimulant Pre-Workout, Kaged Pre-Workout Max

What the Science Says

Nitrosigine is a patented form of arginine bonded with silicate and stabilized by inositol, designed to raise nitric oxide levels more effectively than plain arginine. In a small clinical trial, a single 1.5 g dose increased flow-mediated dilation — a measure of blood vessel flexibility — by about 23%, comparable to 8 g of citrulline malate. Early research also suggests it may support cognitive performance in physically active adults, though this evidence is limited.

What It Doesn't Do

Not proven to directly build muscle or increase strength. No evidence it replaces a full pre-workout on its own. Blood flow improvements don't automatically translate to better athletic performance. Don't assume it works the same as high-dose plain arginine — it's a different compound.

Evidence-Based Benefits

A single 1.5 g dose increases blood vessel dilation by ~23% in healthy active adults.

Weak Evidence

Effective at: 1.5 g

Supporting studies (click to view on PubMed):

PMID 32093766

May support cognitive function in healthy physically active adults.

Weak Evidence

Effective at: 1.5 g

Supporting studies (click to view on PubMed):

PMID 27869715

Absorption & Bioavailability

Good — the inositol-stabilized form is specifically designed to improve arginine absorption and sustain elevated blood arginine levels compared to free-form arginine, which is poorly absorbed at high doses.

Red Flags to Watch For

Only 3 indexed papers available — very limited independent research base for a widely used ingredient
Most research appears industry-funded or conducted by researchers with ties to the patent holder (Nutrition21)
Small sample sizes in available trials (n=24 in the vasodilation study) limit confidence in results
Found in 533+ registered products, suggesting heavy commercial use that outpaces the science

Products Containing Nitrosigine

See how Nitrosigine is used in these analyzed products:

BEYOND RAW (Brand)

Supplement

Mostly Legit

Bucked Up Non-Stimulant Pre-Workout

Supplement

Overhyped

Kaged Pre-Workout Max

Supplement

Mostly Legit

View all product reviews →

Frequently Asked Questions

What does Nitrosigine do?

Patented arginine compound shown to boost blood flow and may support focus in active adults.

What is the effective dose of Nitrosigine?

1.5 g daily based on study doses

Is Nitrosigine safe?

Only 3 indexed papers available — very limited independent research base for a widely used ingredient

What doesn't Nitrosigine do?

Not proven to directly build muscle or increase strength.

Research Sources

PMID 32093766
PMID 27869715
General knowledge — Limited published research available

This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25