Does Oregano Extract Help With Topical 3% oregano extract ointment reduced Staphylococcu...?

Evidence Summary

Topical 3% oregano extract ointment reduced Staphylococcus aureus contamination on post-surgical wounds and improved scar color and pliability compared to petrolatum in a small RCT (PMID: 21968667). In vitro and animal models suggest antioxidant, anti-inflammatory, and antimicrobial properties, including activity against Salmonella (PMID: 34753973) and potential anxiolytic effects in stressed rats (PMID: 35898162). A mouse model showed methanolic oregano extract reduced type 1 diabetes incidence via antioxidant and immunomodulatory mechanisms (PMID: 25671817), though none of these findings have been replicated in human clinical trials.

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Effective Dose

No established dose for humans; animal studies used 50-100 mg/kg; one human trial used 300-600 mg/day total phenolics