Phosphatidylserine Extract
Also known as: PS, phosphatidylserine, soy-derived PS, sunflower PS, bovine cortex PS
Effective Dosage
100-400 mg daily (general knowledge; no study data provided)
What the Science Says
Phosphatidylserine (PS) is a phospholipid — a type of fat — that is naturally found in high concentrations in brain cell membranes. It plays a role in maintaining cell membrane fluidity and supporting communication between neurons. Based on general knowledge (not the provided studies), PS has been most studied for its potential to support memory, attention, and cognitive function in aging adults, with some research suggesting modest benefits at doses of 100–300 mg per day over several weeks to months.
What It Doesn't Do
Won't reverse dementia or Alzheimer's disease. Not a proven treatment for ADHD despite some marketing claims. No solid evidence it boosts athletic performance or builds muscle. Don't expect dramatic cognitive improvements — effects, if real, tend to be modest. Not a substitute for sleep, exercise, or a healthy diet for brain health.
Evidence-Based Benefits
Phosphatidylserine is a phospholipid that plays a key role in cellular function, particularly in the brain. Some studies suggest it may help improve cognitive function, particularly in the elderly, and may reduce exercise-induced stress and improve recovery.
Moderate EvidenceEffective at: 100-300 mg daily
Source: PubMed, NIH DSLD
Absorption & Bioavailability
Moderate — PS is a fat-soluble compound and is generally well absorbed when taken with food. Plant-derived (soy or sunflower) PS is the modern standard since bovine-brain PS was discontinued due to disease concerns. Absorption details from the provided studies are unavailable.
Red Flags to Watch For
- No study abstracts were provided — this profile relies on general knowledge, not reviewed clinical data
- Products sourced from bovine brain (older formulations) carry theoretical disease-transmission concerns; modern products use soy or sunflower sources
- The FDA has only granted a 'qualified health claim' for PS and cognitive decline — meaning evidence is limited and not conclusive
- Some products are dramatically underdosed (below 100 mg) compared to doses used in historical research
- Soy-derived PS may be a concern for individuals with soy allergies — check the source on the label
Research Sources
- General knowledge
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-06