Polygonum Root Extract
Also known as: Fo-Ti, He Shou Wu, Polygonum multiflorum, Fallopia multiflora, Chinese knotweed root
Effective Dosage
No established dose
What the Science Says
Polygonum Root Extract, also known as Fo-Ti or He Shou Wu, is a root extract from Polygonum multiflorum, a plant used for centuries in Traditional Chinese Medicine. It is traditionally associated with anti-aging, hair darkening, and general vitality support. However, no clinical trials were available in the provided research data to confirm any of these effects in humans, and the evidence base remains largely anecdotal or from preliminary laboratory studies.
What It Doesn't Do
No proven ability to reverse gray hair or hair loss. No clinical evidence it extends lifespan or acts as a true anti-aging compound. Not a proven testosterone booster. Won't reliably improve memory or cognition based on available evidence. Not a substitute for medical treatment of any condition.
Evidence-Based Benefits
Polygonum Root Extract, also known as Fo-Ti or He Shou Wu, is a root extract from Polygonum multiflorum, a plant used for centuries in Traditional Chinese Medicine. It is traditionally associated with anti-aging, hair darkening, and general vitality support. However, no clinical trials were available in the provided research data to confirm any of these effects in humans, and the evidence base remains largely anecdotal or from preliminary laboratory studies.
Weak EvidenceEffective at: No established dose
Source: auto-research
Absorption & Bioavailability
Unknown — no clinical pharmacokinetic data was available in the provided studies. Some active compounds like stilbene glycosides and emodin have been studied in isolation, but absorption data in humans from whole extract is lacking.
Red Flags to Watch For
- Documented cases of serious liver toxicity (hepatotoxicity) reported in medical literature — this is a significant safety concern, not a minor side effect
- Banned or restricted in several countries including Australia and Canada due to liver injury reports
- Commonly marketed with dramatic anti-aging and hair restoration claims that have no clinical trial support
- Products may vary widely in preparation — raw (unprocessed) root is considered more toxic than the processed form, but labeling often does not distinguish between them
- Frequently found in hair growth and anti-aging supplements where it is used as a marketing ingredient without meaningful dosing transparency
- No standardized extract or dose has been established, making product-to-product comparisons unreliable
Products Containing Polygonum Root Extract
See how Polygonum Root Extract is used in these analyzed products:
Research Sources
- General knowledge
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-09