Does Tributyrin Help With Tributyrin is a prodrug of butyrate that resists gastric ...?

Evidence Summary

Tributyrin is a prodrug of butyrate that resists gastric acid and is hydrolyzed to butyrate by pancreatic lipases in the small intestine, with approximately 40-49% converted to butyrate in the small intestine and the remainder reaching the colon (PMID: 41473189). In preclinical transplant models, oral tributyrin extended allograft survival via regulatory T cell-mediated immune modulation (PMID: 41554342). A small open-label study in Parkinson's disease patients found it was safe and well-tolerated over 30 days, with preliminary evidence of target engagement on gut-brain axis biomarkers (PMID: 41271518).

Source: auto-research

Effective Dose

500-4000 mg daily (human studies range widely; no consensus established)