Vitex (Chaste Tree Berry)
Also known as: Vitex agnus-castus, chaste tree, chasteberry, VAC, Vitagnus, monk's pepper
Effective Dosage
No established dose from provided studies alone; study doses ranged from 5.8 mg/day (standardized extract) to 200 mg/kg in animal models
What the Science Says
Vitex agnus-castus is a flowering shrub whose berries have been used for centuries to support women's hormonal health. Clinical trials show it can meaningfully reduce PMS symptoms — including psychological and physical complaints — and may improve oxidative stress markers, insulin resistance, menstrual regularity, and HDL cholesterol in women with PCOS. Its proposed mechanisms include modulating dopamine, prolactin, and estrogen receptor pathways, though the exact targets are still being studied.
What It Doesn't Do
Not a proven replacement for estrogen therapy — animal research shows it cannot prevent bone loss from estrogen deficiency the way estradiol can. Not shown to treat low back pain on its own (the studied product combined it with ginger). No evidence it works for men or for conditions unrelated to women's hormonal cycles. Don't expect it to cure PCOS — it may help manage some markers but is not a standalone treatment.
Evidence-Based Benefits
Vitex is primarily used for its potential effects on hormonal balance, particularly in alleviating symptoms of premenstrual syndrome (PMS) and menstrual irregularities. Multiple systematic reviews and clinical trials have shown it may help reduce symptoms associated with hormonal fluctuations.
Strong EvidenceEffective at: 20-40 mg daily
Source: auto-research
Absorption & Bioavailability
Unknown — no pharmacokinetic data provided in the available studies. Standardized extracts (e.g., standardized to aucubin content) are used in clinical trials, suggesting raw berry potency may vary widely.
Red Flags to Watch For
- Most products on the market are not standardized to active compounds — potency can vary dramatically between brands
- Vitex can interact with hormonal medications, dopamine-related drugs, and oral contraceptives — consult a doctor before use
- The PCOS and PMS trials used specific standardized extracts; generic 'chaste berry' capsules may not replicate these results
- Not appropriate during pregnancy or for women undergoing fertility treatments without medical supervision
- Some studies tested multi-ingredient formulas (e.g., Vitex + soy, Vitex + ginger), making it hard to isolate Vitex's individual contribution
Products Containing Vitex (Chaste Tree Berry)
See how Vitex (Chaste Tree Berry) is used in these analyzed products:
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-06