Last verified: 17 days ago
Vitis Vinifera Leaf Extract
Also known as: Grape Leaf Extract, Grapevine Leaf Extract, Red Vine Leaf Extract, Vitis vinifera
Evidence under review. — Not yet rated
Grape leaf extract with antioxidant polyphenols. Human clinical evidence is very limited.
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What it does
Vitis vinifera leaf extract comes from grapevine leaves and contains polyphenols like quercetin and caftaric acid. Lab and animal studies suggest it has antioxidant properties and may reduce...
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Evidence quality
Evidence base hasn't been formally rated yet. See research below.
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Clinical dose
No established dose (insufficient research data)
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Found in
What the Science Says
Vitis vinifera leaf extract comes from grapevine leaves and contains polyphenols like quercetin and caftaric acid. Lab and animal studies suggest it has antioxidant properties and may reduce inflammation. The available research is almost entirely pre-clinical — no human clinical trials were found in the provided data to confirm these effects in people.
What It Doesn't Do
No proven human benefits based on available studies. Don't assume it works like grape seed extract — the leaf is a different product with different evidence. No clinical proof it improves circulation, reduces swelling, or fights disease in humans. The 1,000+ supplement products on the market far outpace the actual human research.
Evidence-Based Benefits
Contains polyphenols that show antioxidant activity in lab and food science studies.
Weak EvidenceEffective at: No established dose
Supporting studies (click to view on PubMed):
Animal studies suggest it may reduce inflammation caused by parasitic infection.
Weak EvidenceEffective at: No established dose
Supporting studies (click to view on PubMed):
Absorption & Bioavailability
Unknown — one food science study explored nanovesicle encapsulation to improve stability and protect polyphenols through digestion, suggesting standard bioavailability may be a concern, but no human absorption data was provided.
Red Flags to Watch For
- Virtually no human clinical trial data exists in the provided research — effects seen in animals or lab settings may not translate to people
- Over 1,000 supplement products contain this ingredient despite minimal clinical evidence supporting human use
- Most available research focuses on veterinary or food science applications, not human health
- Marketing claims about vein health or antioxidant benefits are not backed by the provided clinical evidence
Products Containing Vitis Vinifera Leaf Extract
See how Vitis Vinifera Leaf Extract is used in these analyzed products:
Frequently Asked Questions
What does Vitis Vinifera Leaf Extract do?
Grape leaf extract with antioxidant polyphenols. Human clinical evidence is very limited.
What is the effective dose of Vitis Vinifera Leaf Extract?
No established dose (insufficient research data)
Is Vitis Vinifera Leaf Extract safe?
Virtually no human clinical trial data exists in the provided research — effects seen in animals or lab settings may not translate to people
What doesn't Vitis Vinifera Leaf Extract do?
No proven human benefits based on available studies.
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25