Vitis Vinifera Leaf Extract
Also known as: Grape Leaf Extract, Grapevine Leaf Extract, Red Vine Leaf Extract, Vitis vinifera
Effective Dosage
No established dose (insufficient research data)
What the Science Says
Vitis vinifera leaf extract comes from the leaves of the common grapevine and contains polyphenols like quercetin glucuronide, caftaric acid, and anthocyanins. These compounds have antioxidant properties in lab settings, meaning they can neutralize cell-damaging molecules in test tubes and animal models. The available research is almost entirely pre-clinical — conducted in mice or food science contexts — so it is not yet known whether these effects translate meaningfully to humans.
What It Doesn't Do
No proven benefit for circulation or vein health in humans based on the provided studies. Not shown to reduce inflammation in people. No evidence it detoxifies the body. The antioxidant activity seen in lab dishes does not automatically mean it works the same way inside your body.
Evidence-Based Benefits
Vitis vinifera leaf extract comes from the leaves of the common grapevine and contains polyphenols like quercetin glucuronide, caftaric acid, and anthocyanins. These compounds have antioxidant properties in lab settings, meaning they can neutralize cell-damaging molecules in test tubes and animal models. The available research is almost entirely pre-clinical — conducted in mice or food science contexts — so it is not yet known whether these effects translate meaningfully to humans.
Weak EvidenceEffective at: No established dose (insufficient research data)
Source: auto-research
Absorption & Bioavailability
Unknown — one study explored nanovesicle encapsulation to improve stability through digestion, suggesting standard bioavailability may be poor, but no human absorption data is available from the provided studies.
Red Flags to Watch For
- Nearly all available research is in animals or food science labs — no human clinical trials found in the provided data
- Widely used in over 1,000 registered supplement products despite a very thin evidence base for human health benefits
- Venoactive drug compliance study mentions grape leaf in a drug-class context, but does not provide efficacy data — consumers may confuse regulatory use with proven benefit
- No established safe or effective dose for humans based on the provided studies
Products Containing Vitis Vinifera Leaf Extract
See how Vitis Vinifera Leaf Extract is used in these analyzed products:
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-09