Bacillus subtilis DE111
Also known as: B. subtilis DE111, DE111, spore-forming probiotic DE111
Effective Dosage
1×10^9 CFU daily based on available study data
What the Science Says
Bacillus subtilis DE111 is a spore-forming probiotic bacterium, meaning it survives harsh conditions like stomach acid better than many standard probiotics. Clinical studies suggest it may support gut microbiota balance, modulate immune responses, and improve markers of endothelial (blood vessel) function. Early research in both humans and animals points to potential cardiovascular benefits, particularly in reducing diet-induced endothelial dysfunction, though the exact mechanisms are still being investigated.
What It Doesn't Do
Not proven to treat or prevent cardiovascular disease in humans. Won't fix obesity or reverse metabolic syndrome on its own. No strong evidence it improves gut barrier function directly. Don't expect dramatic immune protection — effects appear modest and strain-specific. Not a replacement for a healthy diet.
Evidence-Based Benefits
Bacillus subtilis DE111 is a probiotic strain that has shown potential benefits for gut health, including improving digestion and enhancing the gut microbiome. Clinical trials suggest it may help reduce gastrointestinal discomfort and support immune function.
Moderate EvidenceEffective at: No established dose
Source: auto-research
Absorption & Bioavailability
Good — as a spore-forming bacterium, DE111 is highly resistant to stomach acid and heat, improving its survival through the GI tract compared to non-spore-forming probiotics. Ileostomy studies confirm it reaches the small intestine intact.
Red Flags to Watch For
- Most studies are small and short-term; long-term safety data in diverse populations is limited
- Several paper abstracts in the provided data were incomplete or truncated, limiting full assessment of findings
- Animal (mouse) studies showing cardiovascular benefits may not directly translate to humans
- Over 1,000 registered supplement products contain this ingredient, but most lack independent clinical validation of their specific formulations
- Marketing claims often outpace the actual evidence base, which is still early-stage for most benefits
Products Containing Bacillus subtilis DE111
See how Bacillus subtilis DE111 is used in these analyzed products:
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-06