Last verified: today
Creapure
Also known as: creatine monohydrate, Creapure® creatine, micronized creatine monohydrate, CrM
Evidence under review. — Not yet rated
Pharmaceutical-grade creatine monohydrate. Boosts strength, power, and muscle creatine stores.
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What it does
Creapure is a trademarked, pharmaceutical-grade form of creatine monohydrate manufactured in Germany by AlzChem AG. It works by increasing the amount of creatine stored in your muscles, which...
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Evidence quality
Evidence base hasn't been formally rated yet. See research below.
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Clinical dose
3-5 g/day maintenance; 20 g/day (4x5g) loading phase for 5-7 days
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Found in
Onnit, Asitisnutrition, Nutricost Micronized Creatine Monohydrate and 3 more
What the Science Says
Creapure is a trademarked, pharmaceutical-grade form of creatine monohydrate manufactured in Germany by AlzChem AG. It works by increasing the amount of creatine stored in your muscles, which fuels short bursts of high-intensity exercise like sprinting or heavy lifting. Studies using Creapure show it reliably raises muscle creatine content and improves anaerobic power output, with benefits typically appearing within 5–7 days of loading or 3–4 weeks of lower-dose supplementation.
What It Doesn't Do
Being 'Creapure' doesn't make it more effective than other quality creatine monohydrate products — it's the same molecule. Buffered or 'pH-corrected' creatine products (like Kre-Alkalyn) are not superior to Creapure despite higher price tags. Creatine won't build muscle without resistance training. It won't improve endurance sports like long-distance running. It's not a steroid or hormone booster.
Evidence-Based Benefits
Significantly increases muscle creatine stores within 5–7 days of supplementation.
Strong EvidenceEffective at: 20 g/day (loading) or 10 g/day for 5 days
Improves anaerobic sprint capacity, including mean power and total work output.
Moderate EvidenceEffective at: 10–20 g/day
Supports increases in 1-rep max strength in resistance-trained individuals over 4 weeks.
Moderate EvidenceEffective at: 5 g/day maintenance after loading
Pharmaceutical-grade purity (≥99.9%) reduces exposure to manufacturing byproducts found in lower-quality creatine.
Weak EvidenceEffective at: 3–5 g/day
Absorption & Bioavailability
Good — creatine monohydrate is well-absorbed orally. Muscle uptake is enhanced when taken with carbohydrates or protein. Creapure's purity (≥99.9% creatine monohydrate) minimizes impurities like creatinine or dicyandiamide found in lower-grade products.
Red Flags to Watch For
- Products claiming Creapure is dramatically superior to all other creatine forms are overstating the evidence — the key advantage is purity and manufacturing quality, not a fundamentally different mechanism.
- Buffered creatine products (e.g., Kre-Alkalyn) are often marketed as better than creatine monohydrate at lower doses — research directly contradicts this claim.
- Serum creatinine levels rise with creatine supplementation, which can falsely flag as kidney stress on standard blood tests — this is expected and not a sign of kidney damage in healthy individuals.
- Loading phases (20 g/day) may cause temporary water retention and GI discomfort in some users — splitting doses throughout the day reduces this risk.
Products Containing Creapure
See how Creapure is used in these analyzed products:
Research Sources
- PMID: 22971354
- PMID: 24568653
- General knowledge — creatine monohydrate is one of the most extensively studied sports supplements; Creapure is a specific trademarked form
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25