Rebaudioside M
Also known as: Reb M, Stevia Rebaudioside M, StRebM, Rebaudoside M, E960c, steviol glycoside
Effective Dosage
No established dose (insufficient research data)
What the Science Says
Rebaudioside M (Reb M) is a next-generation steviol glycoside — a natural, zero-calorie sweetener extracted or bioconverted from the stevia plant. In a clinical trial of adults with overweight or obesity, biscuits sweetened with Reb M produced lower postprandial blood glucose and insulin responses compared to sugar-sweetened biscuits, without reducing appetite satisfaction. Animal studies suggest it does not worsen obesity, liver health, or metabolic markers, and may positively influence gut microbiota. Regulatory bodies including EFSA have evaluated its safety and established an Acceptable Daily Intake of 4 mg/kg body weight for steviol glycosides as a class.
What It Doesn't Do
Won't help you lose weight on its own — appetite was no different from sugar in the one clinical trial. Not proven to treat diabetes or metabolic disease. No evidence it boosts energy, improves athletic performance, or detoxifies anything. The gut microbiota benefits seen in mice haven't been confirmed in humans. Don't confuse it with a health supplement — it's primarily a food additive.
Evidence-Based Benefits
Rebaudioside M (Reb M) is a next-generation steviol glycoside — a natural, zero-calorie sweetener extracted or bioconverted from the stevia plant. In a clinical trial of adults with overweight or obesity, biscuits sweetened with Reb M produced lower postprandial blood glucose and insulin responses compared to sugar-sweetened biscuits, without reducing appetite satisfaction. Animal studies suggest it does not worsen obesity, liver health, or metabolic markers, and may positively influence gut microbiota. Regulatory bodies including EFSA have evaluated its safety and established an Acceptable Daily Intake of 4 mg/kg body weight for steviol glycosides as a class.
Weak EvidenceEffective at: No established dose (insufficient research data)
Source: auto-research
Absorption & Bioavailability
Poor (as intended) — Reb M is not absorbed in the upper GI tract. It passes to the colon where gut bacteria hydrolyze it to steviol, which is then absorbed. This is what gives it negligible caloric impact.
Red Flags to Watch For
- Only one small human clinical trial (n=53) exists in the provided data — evidence base is very thin for health claims
- Most production uses genetically modified yeast (Yarrowia lipolytica) via bioconversion — consumers seeking 'natural' stevia should check the source
- Reb M/mogroside V blends show no sweetness synergy, meaning some product formulations may use higher doses to achieve desired sweetness
- Long-term human safety data beyond two weeks is not available in the provided studies
- Widely used in 1000+ registered supplement and food products despite very limited clinical research
Products Containing Rebaudioside M
See how Rebaudioside M is used in these analyzed products:
Research Sources
- PubMed
- NIH DSLD
This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-04-08