Maltodextrin

Also known as: MDX, glucose polymer, starch hydrolysate, maltodextrin-based carbohydrate

Evidence under review. — Not yet rated

Common food additive used as a placebo in clinical trials. Not a therapeutic supplement.

What it does

Maltodextrin is a processed starch-derived carbohydrate made by partially breaking down starch from corn, wheat, or potato. In the research literature, it appears almost exclusively as an inert...
Evidence quality

Evidence base hasn't been formally rated yet. See research below.
Clinical dose

No established dose
Found in

1.M.R OG Pre-Workout Formula, SlimFast High Protein Shakes, Solaray Bean Enzyme 30 GaIU and 14 more

What the Science Says

Maltodextrin is a processed starch-derived carbohydrate made by partially breaking down starch from corn, wheat, or potato. In the research literature, it appears almost exclusively as an inert placebo comparator in clinical trials — not as an active therapeutic ingredient. One study used a 12.5% maltodextrin drink before cardiac surgery as a carbohydrate-loading strategy, with modest and non-significant effects on insulin resistance. It is also used industrially as an encapsulation agent to stabilize powdered food and supplement formulations.

What It Doesn't Do

Not a health supplement. No evidence it improves gut health, boosts immunity, or enhances athletic performance. It is not a prebiotic — studies use it specifically because it has no prebiotic effect. Won't reduce insulin resistance in cardiac surgery patients. No evidence it supports weight loss, cognition, or any specific health outcome.

Evidence-Based Benefits

Effectively stabilizes and preserves bioactive compounds in powdered supplement formulations.

Weak Evidence

Effective at: Varies by formulation

Supporting studies (click to view on PubMed):

PMID 42073241

A 12.5% maltodextrin drink before surgery may modestly stabilize insulin levels but does not significantly reduce insulin resistance.

Weak Evidence

Effective at: 400 mL of 12.5% solution (~50 g) 2 hours preoperatively

Supporting studies (click to view on PubMed):

PMID 41979300

Absorption & Bioavailability

Good — rapidly digested and absorbed as glucose; high glycemic index

Red Flags to Watch For

Rapidly raises blood sugar — unsuitable for people with diabetes or insulin resistance
Often used as a cheap filler or bulking agent in supplements without therapeutic benefit
High glycemic index means it can cause blood sugar spikes similar to table sugar
Frequently listed as an 'inactive' ingredient but contributes calories and carbohydrates

Supplement

Misleading

True Nutrition Flavor Packs (50g)

Supplement

Legitimate

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Frequently Asked Questions

What does Maltodextrin do?

Common food additive used as a placebo in clinical trials. Not a therapeutic supplement.

What is the effective dose of Maltodextrin?

No established dose

Is Maltodextrin safe?

Rapidly raises blood sugar — unsuitable for people with diabetes or insulin resistance

What doesn't Maltodextrin do?

Not a health supplement.

Research Sources

PubMed
NIH DSLD

This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-05-25