Does Shilajit Help With At 500 mg/day over 8 weeks, shilajit (PrimaVie®) reduced ...?

Evidence Summary

At 500 mg/day over 8 weeks, shilajit (PrimaVie®) reduced fatigue-induced decline in maximal voluntary isometric contraction in the upper 50th percentile of recreationally active men and elevated serum hydroxyproline levels (PMID 30728074). An 8-week RCT found no significant increase in serum Pro-c1α1 collagen synthesis biomarker versus placebo (PMID 36546868). A 28-day open-label pilot (no control group) reported improvements in muscle strength, endurance, VO₂ max, fatigue scores, and CRP reduction, though the lack of a placebo arm severely limits interpretation (PMID 41613504). Preclinical data suggest hepatoprotective effects via NF-κB/AKT/Caspase-3 pathways (PMID 40957543) and in vitro wound-healing promotion in periodontal ligament cells (PMID 40057709), but these findings have not been confirmed in human trials.

Source: auto-research

Effective Dose

500 mg/day based on most consistent study doses