Does Resveratrol Help With Resveratrol at 500 mg/day significantly reduced pain, imp...?

Evidence Summary

Resveratrol at 500 mg/day significantly reduced pain, improved WOMAC scores, gait velocity, handgrip strength, and range of motion in knee osteoarthritis patients over 12-18 weeks, with effects potentially mediated by increased plasma SIRT1 and reduced CRP and oxidative stress markers (PMIDs: 41037125, 41679011). Combined oral (75 mg) and topical (1.5% cream) trans-resveratrol reduced wrinkle scores in women over 40 after 8 weeks compared to placebo (PMID: 41488277). Pre-clinical and in vitro data suggest radioprotective effects on endothelial cells and potential chemosensitizing properties, though these lack clinical validation (PMIDs: 41934924, 41895749).

Source: auto-research

Effective Dose

500 mg/day based on clinical trials in knee OA; lower doses used in skin studies (75 mg oral + topical)