Hormone Harmony PLUS+ Review 2026: Legit or Overhyped?

Possible side effects

• The most common complaints are diarrhea, nausea, abdominal cramps, and other digestive upset.

Serious risks

• High intakes may raise urinary oxalate and uric acid, which could contribute to kidney stones, especially in people with renal disorders.
• The best evidence that vitamin C contributes to kidney stones is in patients who already have hyperoxaluria.
• In people with hereditary hemochromatosis, long-term high doses could worsen iron overload and cause tissue damage.
• A few in vitro studies suggested that supplemental oral vitamin C, acting as a pro-oxidant, could cause chromosomal or DNA damage and possibly contribute to cancer.
• In postmenopausal women with diabetes in the Iowa Women's Health Study, supplemental vitamin C of at least 300 mg/day was significantly associated with a higher risk of dying from CVD.

Avoid or ask a doctor first if

• People with hereditary hemochromatosis face a concern about iron overload with chronic high doses.
• The upper limits do not apply to people receiving vitamin C as medical treatment, who should be under a physician's care.
• Infants should get vitamin C only from formula and food.

Medication interactions

• Vitamin C supplements may interact with radiation therapy and with medications, including chemotherapy drugs and statins.
• People taking these medications regularly should talk with their health care providers about vitamin C intake.

Serious risks

• Some sage species, including common sage, contain thujone, which can be toxic in large amounts. Sage may be unsafe in high doses or when used for long periods.

Avoid or ask a doctor first if

• Using sage during pregnancy may be unsafe because of thujone. Talk with a health care provider first if you're considering it.
• Little is known about whether sage is safe while breastfeeding.

Medication interactions

• No sage-specific drug interactions are named. The source advises talking with a provider before using any herbal product if you take medicine, because some herbs and medicines interact in harmful ways.

Possible side effects

• Side effects are usually minor and consist of self-limited gastrointestinal symptoms such as gas.

Serious risks

• Probiotic use has been linked to bacteremia, fungemia, and infections that led to severe illness, mostly in severely ill or immunocompromised people.
• Severe or fatal infections have been reported in premature infants given probiotics, and the FDA has warned health care providers.
• In a Boston ICU analysis, 6 of 522 patients given LGG had the ingested LGG found in their blood, versus 2 of 21,652 who did not receive it.
• Possible harms include infections, harmful substances produced by the probiotic microorganisms, and transfer of antibiotic resistance genes.
• Some products have contained microorganisms not listed on the label, which in some instances may pose serious health risks.

Avoid or ask a doctor first if

• For high-risk people such as premature infants or seriously ill hospital patients, the risks of probiotics should be carefully weighed against their benefits.
• For people with compromised immune function or other serious underlying diseases, the WGO advises restricting probiotic use to strains and indications with proven efficacy.
• Consult a health care provider before taking a probiotic supplement, especially with health problems. Anyone with a serious underlying condition should be monitored closely.

Avoid or ask a doctor first if

• The recommended intakes don't apply to people whose bodies clear potassium poorly, for example because of kidney disease or certain medications.
• People taking medications that affect potassium should talk with their health care providers about their potassium intake and status.

Medication interactions

• Several types of medications can affect potassium status in ways that could be dangerous.

Possible side effects

• High iodine intakes can cause goiter, elevated TSH levels, and hypothyroidism, some of the same symptoms as iodine deficiency.

Serious risks

• Iodine-induced hyperthyroidism can result from high iodine intakes, including when iodine is given to treat iodine deficiency.
• Studies have shown that excessive iodine intakes cause thyroiditis and thyroid papillary cancer.
• Acute iodine poisoning is rare and is usually caused by doses of many grams. Symptoms include burning of the mouth, throat, and stomach, fever, abdominal pain, nausea, vomiting, diarrhea, weak pulse, and coma.
• Long-term intakes above the UL increase the risk of adverse health effects.

Avoid or ask a doctor first if

• People with autoimmune thyroid disease or iodine deficiency may have adverse effects at iodine intakes considered safe for the general population.
• The ULs do not apply to people receiving iodine for medical treatment, who should be under a physician's care.

Medication interactions

• Iodine supplements have the potential to interact with several types of medications. People taking these medications on a regular basis should discuss their iodine intakes with their health care providers.