Grape

Also known as: Vitis vinifera, grape seed extract, GSE, grape pomace, Concord grape juice, grape seed polyphenol extract, Vitis labruscana

Evidence under review. — Not yet rated

Grape-derived extracts show early promise for heart health and antioxidant effects, but human evidence is limited.

What it does

Grape is a fruit whose seeds, skin, leaves, and juice contain polyphenols — natural plant compounds with antioxidant properties. A 12-week clinical trial found that grape leaf extract (1800...
Evidence quality

Evidence base hasn't been formally rated yet. See research below.
Clinical dose

No established dose
Found in

Balance of Nature Fruits & Veggies, Bloom Nutrition Greens & Superfoods, 1.M.R OG Pre-Workout Formula and 17 more

See full breakdown ↓ Methodology →

What the Science Says

Grape is a fruit whose seeds, skin, leaves, and juice contain polyphenols — natural plant compounds with antioxidant properties. A 12-week clinical trial found that grape leaf extract (1800 mg/day) reduced platelet aggregation and lowered systolic blood pressure in people with cardiovascular risk factors. Grape seed extract has also been tested as a dental pulp dressing material with results comparable to a standard treatment, though most other human research is still in early trial stages.

What It Doesn't Do

Not proven to treat or prevent cancer — a multi-ingredient nutraceutical trial including grape seed extract showed no significant survival benefit in glioblastoma patients. No solid evidence it reliably reduces stress or boosts mental resilience in healthy adults — that trial is still ongoing. Grape products are not a substitute for prescribed cardiovascular medications. Antioxidant activity measured in a lab tube does not automatically translate to benefits in your body.

Evidence-Based Benefits

Grape leaf extract reduced platelet clumping and lowered systolic blood pressure in adults with heart disease risk.

Weak Evidence

Effective at: 1800 mg/day

Supporting studies (click to view on PubMed):

PMID 40609384

Grape seed extract performed comparably to a standard dental material in children's tooth pulp procedures.

Weak Evidence

Effective at: No established dose

Supporting studies (click to view on PubMed):

PMID 41029033

Absorption & Bioavailability

Poor to Moderate — grape polyphenols like proanthocyanidins have limited intestinal absorption (often below 15%). Microbial metabolism in the gut produces secondary compounds that may carry much of the biological activity. Nanoemulsion formulations are being explored to improve delivery but are not yet standard in supplements.

Red Flags to Watch For

Most grape-related papers in this dataset are about agriculture, pest control, food science, or animal feed — not human health benefits.
The one cardiovascular RCT used a specific grape leaf extract (HP-01) at a precise dose; generic 'grape extract' supplements may not replicate these results.
Grape products grown in agroindustrial zones may carry pesticide residues (neonicotinoids, fungicides); sourcing and testing matter.
Multi-ingredient products containing grape seed extract make it impossible to attribute any benefit specifically to grape.
No established effective dose for any health outcome based on the provided studies.

Legitimate

View all product reviews →

Frequently Asked Questions

What does Grape do?

Grape-derived extracts show early promise for heart health and antioxidant effects, but human evidence is limited.

What is the effective dose of Grape?

No established dose

Is Grape safe?

Most grape-related papers in this dataset are about agriculture, pest control, food science, or animal feed — not human health benefits.

What doesn't Grape do?

Not proven to treat or prevent cancer — a multi-ingredient nutraceutical trial including grape seed extract showed no significant survival benefit in glioblastoma patients.

Research Sources

PubMed
NIH DSLD

This information is for educational purposes only and is not medical advice. Always consult a healthcare professional before starting any supplement regimen. Last updated: 2026-08-31